What nature never thought to make.
70% of drug targets are too complex for small molecules and beyond the reach of biologics. Until now.
to hard targets.
Small Molecules can permeate cells but can’t bind complex targets. Biologics, like antibody therapeutics, can only act on targets displayed outside of cells.
Naturally derived macrocycles evolved to bridge the gap between small molecules and biologics by transcending the traditional boundaries of cell permeability to access deep, complex targets with high specificity.
Macrocycle Discovery Platform
Our AI-enhanced platform creates entirely new drugs by engineering synthetic molecules to mimic nature’s macrocycles. Our platform produces passively permeable, macrocyclic peptides that access and address traditionally undruggable targets.
Unnatural Products for uncommon outcomes.
We’re a California-based biotech company using our platform to tackle the hard targets that will change the future of medicine.
Founded by macrocycle pioneers whose academic work uncovered how Nature’s macrocycles work, UNP is a team of passionate scientists, engineers, and experienced drug developers.